I've tried all other Blueprint, 960 etc . I want make custom framework for custom width and gutters which should be modify for any width or spacing between boxes. I need the best optimize and quick way to make layout. Want to make a reusable framework/method/patteren in css. **For examples:** [![alt text][3]][3] _{(source: [fivetechnology.com](http://www.fivetechnology.com/images/blog/hunting_wireframe1.jpg))} **Edit:** By now i found this article useful http://www.cssnewbie.com/build-custom-frameworks/ would like to know others views. [3]: https://i.stack.imgur.com/YuIOd.jpg